The World Health Organization (WHO) defines a clinical trial as any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes.

Trials posted here are for informational purposes only.  The Alliance does not endorse any particular research study and is not responsible for the accuracy of the information provided by the investigator or the accuracy of the information provided by the searchable databases.

 

 

 

clinical research

development of new treatments

Those participating in clinical trials are volunteers, and are an important tool in the development of better health outcomes for those with pheochromocytoma and paraganglioma. In this section, we explain the types of clinical trials and provide tools to help you decide if a clinical trial may be right for you.

Use the searchable clinical trial databases below to find pheo and para clinical trials. In addition, the following research participation opportunities are listed at the request of the investigator.

Caregivers’ Experiences in Accessing Mental Health Treatment for their Children

Find more information and participate in the survey here. English & Spanish

Study Information Provided by the Investigator

Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer

Find more information on the trial here.

Trial Information Provided by the Investigator

Dosimetry Guided PRRT With 177Lu-DOTATATE in Children and Adolescents

To find more information go to clinicaltrials.gov and search for NCT03923257

Trial Information Provided by the Investigator

Genomic Services Research Program

To find more information go to this page on clinicaltrials.gov

Trial information Provided by the Investigator

Clinical Research Sources


Clinicaltrials.gov
ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world.
ICTRP

Sponsored by the World Health Organization, the International Clinical Trials Search Portal provides access to a central database containing the trial registration data.

Note: Search results can sometimes be enhanced by broadening your search terms, such as trying both “paraganglioma” and “carotid body tumor”.

Types of Clinical Trials


Diagnostic Trials

Diagnostic trials determine better tests or procedures for diagnosing a particular disease or condition.

Natural History Studies

Natural history studies provide valuable information about how disease and health progress.

Prevention Trials

Prevention trials look for better ways to prevent a disease in people who have never had the disease or to prevent the disease from returning.

Quality of Life Trials

Quality of life trials (or supportive care trials) explore and measure ways to improve the comfort and quality of life of people with a chronic illness.

Screening Trials

Screening trials test the best way to detect certain diseases or health conditions.

Treatment Trials

Participation in clinical trials for those with progressive disease is critical to finding new treatments for pheo para.  Treatment trials test new treatments, new combinations of drugs, or new approaches to surgery or radiation therapy.

Phases of Clinical Trials

Clinical trials are conducted in “phases.” The trials at each phase have a different purpose and help researchers answer different questions.


Phase I Trials 

An experimental drug or treatment in a small group of people (20–80) for the first time. The purpose is to evaluate its safety and identify side effects.

Phase II Trials 

The experimental drug or treatment is administered to a larger group of people (100–300) to determine its effectiveness and to further evaluate its safety.

Phase III Trials 

The experimental drug or treatment is administered to large groups of people (1,000–3,000) to confirm its effectiveness, monitor side effects, compare it with standard or equivalent treatments.

Phase IV Trials 

After a drug is licensed and approved by the FDA researchers track its safety, seeking more information about its risks, benefits, and optimal use.

To learn more about Clinical Trials, check out the American Cancer Society’s “Clinical Trials: What You Need to Know”.